Lower resting pulmonary function, such as FVC <81% predicted versus >96% predicted, was significantly predictive of increased death or transplant in heart failure patients (P<0.001).
Cohort (n=134)
p-value: p=<0.001
BACKGROUND: The heart and lungs are intimately linked anatomically and physiologically, and, as a result, heart failure (HF) patients often develop changes in pulmonary function. This study examined the prognostic value of resting pulmonary function (PF) in HF. METHODS AND RESULTS: In all, 134 HF patients (enrolled from January 1, 1999 Through December 31, 2005; ejection fraction (EF) = 29% ± 11%; mean age = 55 ± 12 years; 65% male) were followed for 67 ± 34 months with death/transplant confirmed via the Social Security Index and Mayo Clinic registry. PF included forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), diffusing capacity of the lungs for carbon monoxide (DLCO), and alveolar volume (VA). Patients were divided in tertiles according to PF with survival analysis via log-rank Mantel-Cox test with chi-square analysis. Groups for FVC included (1) >96%, (2) 96% to 81%, and (3) 94%, (2) 94% to 77%, and (3) 90%, (2) 90% to 75%, and (3) 97%, (2) 97% to 87%, and (3) <87% predicted (Chi-square = 8.5, P = 0.01). BC suggested differences between groups 1 and 2 (P = 0.014) and 1 and 3 (P = 0.003). CONCLUSIONS: In a well-defined cohort of HF patients, resting measures of PF are predictive of all-cause mortality.
Olson et al. (Tue,) conducted a cohort in Heart failure (n=134). Resting pulmonary function vs. Higher resting pulmonary function (tertiles) was evaluated on Death or transplant (p=<0.001). Lower resting pulmonary function, such as FVC <81% predicted versus >96% predicted, was significantly predictive of increased death or transplant in heart failure patients (P<0.001).