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May 29, 2026Materials & DesignOpen Access

Ultrasound-triggered “piezoelectric-chemical” synergy in a smart hydrogel for enhanced craniomaxillofacial bone regeneration

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Authors

XZXi ZhangLYLu YuYLYuanyuan Liu

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Overview

Randomized trial examines enhanced bone regeneration in craniomaxillofacial defects, suggesting effective treatment methods.

Key Points

  • This research aims to develop a smart hydrogel that enhances bone regeneration through combined physical and chemical signals.
  • Created a hydrogel incorporating BaTiO3 and naringin for controlled drug release.
  • Utilized ultrasound to trigger the release of osteogenic drugs.
  • Tested the hydrogel in rat models with critical-sized calvarial defects.
  • The hydrogel facilitated significant bone formation in treated defects compared to controls.
  • Demonstrated effective drug release and osteogenic activity due to ultrasound activation.

Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/6a192d13fab5b468c4415dbchttps://doi.org/10.1016/j.matdes.2026.116299
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