Synthesis of Masked α, β-Unsaturated Trifluoromethyl Ketones via Iodine(III)-Mediated Double Decarboxylative Trifluoroacetylation

Nan Xia; Ming-Chao Li; Jie Zhou; Jun Xu; Hua‐Jian Xu

doi:10.1039/d6ob00763e

January 1, 2026Organic & Biomolecular Chemistry

Synthesis of Masked α, β-Unsaturated Trifluoromethyl Ketones via Iodine(III)-Mediated Double Decarboxylative Trifluoroacetylation

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Key Points

To explore a metal-free method for the synthesis of masked α, β-unsaturated trifluoromethyl ketones.
Utilized iodine(III) for decarboxylative trifluoroacetylation
Employed PhI(OCOMe)₂ as a reagent
Focused on masked α, β-unsaturated carboxylic acids and cyclic CF₃-pyruvate acetals.
Successfully synthesized trifluoromethyl ketones from masked α, β-unsaturated carboxylic acids.
Demonstrated the efficiency of the metal-free protocol.
Available data indicate high reaction yields.

Implication

Demonstrates effective synthesis of trifluoromethyl ketones in masked carboxylic acids, indicating broad synthetic utility.

Abstract

An iodine(III)-mediated double decarboxylative trifluoroacetylation of masked α, β-unsaturated carboxylic acids with cyclic CF₃-pyruvate acetals is reported. This metal-free protocol employs PhI(OCOMe)₂ as a dual-function decarboxylative reagent to forge the...

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Cite This Study

Xia et al. (2026) studied this question.

synapsesocial.com/papers/6a192d4afab5b468c44161fd https://doi.org/10.1039/d6ob00763e

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Synthesis of Masked α, β-Unsaturated Trifluoromethyl Ketones via Iodine(III)-Mediated Double Decarboxylative Trifluoroacetylation

Key Points

Implication

Abstract

Discussion

Cite This Study

Synthesis of Masked α, β-Unsaturated Trifluoromethyl Ketones via Iodine(III)-Mediated Double Decarboxylative Trifluoroacetylation

Key Points

Implication

Abstract

Discussion

Cite This Study

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