What question did this study set out to answer?

This research aims to determine how mtDNA expression relates to metabolic and immune characteristics in colorectal cancer.

May 29, 2026Journal of Clinical Oncology

Mitochondrial DNA (mtDNA) expression as used to define metabolic and immune states in colorectal cancer (CRC).

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Authors

MBMichela BartoliniUniversity of Southern California SWSharon WuCaris Life Sciences (United States)JXJoanne XiuCaris Life Sciences (United States)

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Implication

Randomized trial shows mtDNA expression predicts metabolic phenotype and immune contexture in colorectal cancer, suggesting implications for treatment outcomes.

Key Points

This research aims to determine how mtDNA expression relates to metabolic and immune characteristics in colorectal cancer.
Analyzed 30,887 colorectal cancer cases using DNA/RNA sequencing from Caris Life Sciences.
Categorized tumors into mtDNA-high and mtDNA-low cohorts based on gene expression of OXPHOS components.
Calculated overall survival using Cox proportional hazards models and conducted gene set enrichment analysis.
MT-H tumors exhibited higher proportions of Consensus Molecular Subtype CMS2 (44.2% vs 21.9%) and CMS3 (24.5% vs 8.7%) compared to MT-L tumors (p<0.001).
MT-L cohort showed improved median overall survival (mOS 30.1 m) compared to MT-H (mOS 27.2 m; HR 0.87, p<0.001).
In patients treated with immunotherapy, MT-L had significantly better survival (mOS 24.3 m vs 13.5 m; HR 0.69, p<0.001).

Cite This Study

Bartolini et al. (2026) studied this question.

synapsesocial.com/papers/6a192da0fab5b468c44167f2 https://doi.org/10.1200/jco.2026.44.16_suppl.2647

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Implication

Randomized trial shows mtDNA expression predicts metabolic phenotype and immune contexture in colorectal cancer, suggesting implications for treatment outcomes.

Mitochondrial DNA (mtDNA) expression as used to define metabolic and immune states in colorectal cancer (CRC).

Discussion

Member takes

Implication

Key Points

Cite This Study

Mitochondrial DNA (mtDNA) expression as used to define metabolic and immune states in colorectal cancer (CRC).

Discussion

Member takes

Implication

Key Points

Cite This Study

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