Adolescent Depression Characterized by Non-Suicidal Self-Injury Behaviors and Its Correlation with Inflammatory Factors, Brain-Derived Neurotrophic Factor, and Childhood Traumas
Randomized trial examines associations between NSSI, trauma, and inflammatory markers in adolescents, suggesting targeted interventions are needed.
Key Points
The aim is to explore the relationship between adolescent depression characterized by non-suicidal self-injury, inflammatory factors, BDNF levels, and childhood traumas.
Recruited 110 patients aged 12-18 with first-episode depression from an outpatient clinic over 10 months.
Divided participants into two groups: those with NSSI (57) and without NSSI (53).
Conducted correlation and logistic regression analyses on trauma scores, depression, anxiety, BDNF, and inflammatory markers.
The NSSI group showed significantly higher rates of childhood trauma, depression, and anxiety compared to the non-NSSI group.
Levels of IL-4 and IL-6 were elevated while BDNF was reduced in the NSSI group.
Emotional abuse and IL-6 were identified as independent risk factors for NSSI.