Diastereoselective assembly of complex benzofuran-annulated spiro-tetrahydroquinoline frameworks via Povarov cyclization

Key Points

• This research aims to explore a novel Povarov reaction with regioselective properties to create complex benzofuran structures.
• Implemented a regioselectively reversed Povarov reaction based on DFT calculations.
• Assessed broad substrate scope and functional-group tolerance.
• Demonstrated gram-scale applicability of the methodology.
• Achieved high diastereoselectivity in substrate transformations.
• Showed functional-group tolerance across various substrates.
• Established practical application on a gram scale.