Channeling teamwork: ATP and lipids cooperate to gate P2X receptors

Frank Bosmans; Toshimitsu Kawate

doi:10.1126/sciadv.aei2053

May 27, 2026Science AdvancesOpen Access

Channeling teamwork: ATP and lipids cooperate to gate P2X receptors

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Key Points

This study aims to understand the interactions between ATP and lipids in gating P2X receptors.
P2X receptor structures were resolved in a lipid environment.
Analysis was conducted to explore ligand recognition and drug sensitivity.
Gating mechanisms were examined in relation to lipid presence.
Ligand recognition varies significantly across receptor subtypes.
Lipids influence drug sensitivity and channel gating.
ATP binding is intricately linked to lipid interactions.

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Implication

Experimental observations reveal how ATP and lipids regulate P2X receptor function, suggesting new therapeutic targets.

Abstract

P2X receptor structures resolved in a lipid environment reveal how subtype-specific ligand recognition, drug sensitivity, and channel gating are coupled.

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Cite This Study

Bosmans et al. (2026) studied this question.

synapsesocial.com/papers/6a192dd1fab5b468c4416c52 https://doi.org/10.1126/sciadv.aei2053

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Channeling teamwork: ATP and lipids cooperate to gate P2X receptors

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Channeling teamwork: ATP and lipids cooperate to gate P2X receptors

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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