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May 29, 2026Journal of Clinical Oncology

Influence of pelareorep on mutant KRAS-specific blood TIL clonal expansion.

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Authors

RTRichard Trauger

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Overview

Randomized trial explores pelareorep's effect on TIL expansion in cancer patients, suggesting immune activation mechanisms.

Key Points

  • The study aims to investigate how pelareorep immunotherapy activates mutant KRAS-specific T cell clones to combat tumor growth.
  • Translational samples from breast and pancreatic cancer trials were analyzed.
  • Tumor gene expression was assessed using RNA extraction from clinical samples at different treatment times.
  • Anti-reovirus T cell responses were measured with ELISPOT and TCRβ CDR3 DNA sequencing.
  • Significant increase in immune gene expression and TLR3 activation post-pelareorep therapy.
  • Expansion of tumor-infiltrating lymphocytes was noted in both tumor and blood samples.
  • Correlation between the expansion of mKRAS-specific T cells and reductions in tumor volume in pancreatic cancer patients.

Cite This Study

Richard Trauger (2026) studied this question.

synapsesocial.com/papers/6a192de6fab5b468c4416df3https://doi.org/10.1200/jco.2026.44.16_suppl.2664
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