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May 29, 2026Journal of Clinical Oncology

Does resection of cavity shave margins impact survival in breast cancer patients?

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Authors

ACAnees B. ChagparYale UniversityKGKristalyn K. GallagherUniversity of North Carolina at Chapel HillCGCarlos Garcia-CantuDoctors Hospital at Renaissance

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Implication

Randomized trial assesses survival outcomes with cavity shave margins in breast cancer patients, suggesting radiation is key for better outcomes.

Key Points

  • This research aims to determine whether resection of cavity shave margins affects overall and disease-free survival in breast cancer patients.
  • Randomized controlled trials SHAVE and SHAVE2 enrolled 631 patients between 2011 and 2018.
  • Patients underwent partial mastectomy and were randomized to 'shave' or 'no shave' arms intraoperatively.
  • Both groups were followed for a median of 60.4 months to assess local recurrence and survival outcomes.
  • Shave group had significantly lower positive margin rate (14.0% vs. 34.8%, p < 0.001).
  • No significant differences in 5-year disease-free survival (91.9% vs. 92.6%, p = 0.820) or overall survival (93.5% vs. 93.5%, p = 0.841) between groups.
  • Using radiation therapy was associated with significantly improved DFS (HR: 0.47; 95% CI: 0.256-0.865, p = 0.015).

Cite This Study

Chagpar et al. (2026) studied this question.

synapsesocial.com/papers/6a192df7fab5b468c4416ecahttps://doi.org/10.1200/jco.2026.44.16_suppl.513
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abstract PO2-03-03: The Significance of Cavity Shave Margins in Breast Carcinoma on Margin Status and Re-excision Rates2024
  2. 2Abstract PO2-23-01: Selective cavity margin shaving: effective method to maintain balance between cosmesis and negative margin in breast conserving surgery2024
  3. 3Impact of cavity shave margins in patients with ductal carcinoma in situ undergoing conserving breast surgery2024 · 4 citations
  4. 4Margin Assessment in Breast-Conserving Surgery: A Comparative Analysis of Frozen Section and Cavity Shave Techniques2026
  5. 5704 Usefulness of systematic cavity shaving during conservative breast cancer surgery: a retrospective study2024