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May 29, 2026Sensors & DiagnosticsOpen Access

Highly sensitive pH-modulated paper-based platform for point-of-care osteopontin quantification in osteoporosis screening

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Authors

AKAmandeep KaurVVikasSSSanjeev Soni

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Overview

Randomized trial evaluates a colorimetric biosensor for osteopontin detection, suggesting improved osteoporosis screening.

Key Points

  • The aim is to develop a sensitive platform for detecting osteopontin, a biomarker for osteoporosis.
  • Developed a paper-based colorimetric biosensor using AuNP@Ab conjugates and phenol red.
  • Immunocomplex formation led to a visible color change for quantification of osteopontin.
  • Color changes were measured using ImageJ for accurate detection.
  • The biosensor successfully detected osteopontin with a clear colorimetric response indicating biomarker presence.
  • Quantification showed reliable results correlating with known concentrations of osteopontin, enhancing screening accuracy.

Cite This Study

Kaur et al. (2026) studied this question.

synapsesocial.com/papers/6a192e39fab5b468c441737dhttps://doi.org/10.1039/d6sd00030d
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