Highly sensitive pH-modulated paper-based platform for point-of-care osteopontin quantification in osteoporosis screening

Amandeep Kaur; Vikas; Sanjeev Soni; SB Singh

doi:10.1039/d6sd00030d

January 1, 2026Sensors & DiagnosticsOpen Access

Highly sensitive pH-modulated paper-based platform for point-of-care osteopontin quantification in osteoporosis screening

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Key Points

The aim is to develop a sensitive platform for detecting osteopontin, a biomarker for osteoporosis.
Developed a paper-based colorimetric biosensor using AuNP@Ab conjugates and phenol red.
Immunocomplex formation led to a visible color change for quantification of osteopontin.
Color changes were measured using ImageJ for accurate detection.
The biosensor successfully detected osteopontin with a clear colorimetric response indicating biomarker presence.
Quantification showed reliable results correlating with known concentrations of osteopontin, enhancing screening accuracy.

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Implication

Evaluates a colorimetric biosensor for osteopontin detection, suggesting improved osteoporosis screening.

Abstract

Paper-based colorimetric biosensors detect osteoporosis biomarker osteopontin (OPN) using AuNP@Ab conjugates and phenol red. Immunocomplex formation induces a visible color change, quantified with ImageJ.

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Cite This Study

Kaur et al. (2026) studied this question.

synapsesocial.com/papers/6a192e39fab5b468c441737d https://doi.org/10.1039/d6sd00030d

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Highly sensitive pH-modulated paper-based platform for point-of-care osteopontin quantification in osteoporosis screening

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Highly sensitive pH-modulated paper-based platform for point-of-care osteopontin quantification in osteoporosis screening

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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