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May 29, 2026Biochemistry and Cell Biology

PPP2R2B targets the JAK2-STAT3 signaling pathway to regulate ferroptosis in breast cancer cells

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Authors

WLWeiming LuoMYMei YangYTYue Tan

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Overview

Randomized trial reveals PPP2R2B's role in regulating ferroptosis in breast cancer, indicating a potential therapeutic target.

Key Points

  • This research investigates the role of PPP2R2B in regulating cell proliferation, migration, and ferroptosis in breast cancer cells.
  • Bioinformatic analysis identified PPP2R2B's role in prognosis and ferroptosis.
  • Breast cancer cells underwent PPP2R2B overexpression or knockdown to assess effects on proliferation and apoptosis.
  • Tumor xenograft model in nude mice evaluated the effect of PPP2R2B on tumor growth in vivo.
  • PPP2R2B down-regulation in breast cancer tissues indicates poor prognosis.
  • PPP2R2B overexpression significantly inhibited cell proliferation and migration in MCF-7 and MDA-MB-231 cells.
  • PPP2R2B enhanced erastin-induced ferroptosis by regulating ferroptosis-related proteins and inhibited JAK2-STAT3 phosphorylation.

Cite This Study

Luo et al. (2026) studied this question.

synapsesocial.com/papers/6a192e4efab5b468c44174bdhttps://doi.org/10.1139/bcb-2025-0361
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1PPP1R14B promotes ferroptosis resistance via YAP1/SLC3A2 signaling in cervical cancer2026
  2. 2PPP2R2C confers radioresistance in nasopharyngeal carcinoma by suppressing ferroptosis via RPS27L stabilization2026
  3. 3PPP2R1B abolishes colorectal cancer liver metastasis and sensitizes Oxaliplatin by inhibiting MAPK/ERK signaling pathway2024 · 11 citations
  4. 4TFCP2L1 suppresses breast cancer progression by promoting ferroptosis through direct and PI3K/AKT-mediated inhibition of GPX42026
  5. 5RSPO2-induced ferroptosis via PTBP1-mediated FSP1 mRNA decay suppresses breast cancer progression2026