PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
May 29, 2026Journal of Clinical Oncology

Impact of concomitant antibiotic exposure on overall survival in patients with esophagogastric cancer treated with immune checkpoint inhibitors: A real-world cohort study.

View Full Paper
Ask AI
Bookmark
Share

Authors

DMDiptasree MukherjeeAKArunkumar Krishnan

Discussion

Loading...

Member takes

Overview

Cohort study evaluates antibiotic impact on overall survival in esophagogastric cancer, indicating caution with antibiotic use.

Key Points

  • This research aims to examine the effects of antibiotic exposure on overall survival in esophagogastric cancer patients receiving immune checkpoint inhibitors.
  • Conducted a retrospective cohort study using the TriNetX Global Collaborative Network.
  • Matched patients based on various baseline characteristics including age, sex, and comorbidities.
  • Analyzed overall survival using Kaplan-Meier and Cox proportional hazards models.
  • Antibiotic exposure was linked to worse overall survival with median OS of 10.6 months vs. 14.3 months for non-exposed patients (log-rank p < 0.001).
  • Independent hazard ratio for inferior OS due to antibiotic exposure was HR 1.34 (95% CI 1.22–1.47).
  • The negative impact increased for those exposed to broad-spectrum antibiotics (HR 1.41) and within 30 days prior to ICI initiation (HR 1.38).

Cite This Study

Mukherjee et al. (2026) studied this question.

synapsesocial.com/papers/6a192e79fab5b468c44178b4https://doi.org/10.1200/jco.2026.44.16_suppl.11160
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Impact of pre-treatment antibiotic exposure on immunotherapy outcomes in gastrointestinal malignancies: A multicenter propensity-matched real-world cohort study.2026
  2. 2Disrupting the microbiome, disrupting immunity: Antibiotic exposure and survival outcomes with immune checkpoint inhibitors—A systematic review.2026
  3. 3Impact of concurrent antibiotics on survival with immunotherapy in metastatic colorectal and pancreatic cancer.2024
  4. 4The impact of antibiotic use in gastrointestinal tumors treated with immune checkpoint inhibitors: systematic review and meta-analysis2024 · 2 citations
  5. 5Impact of proton pump inhibitors and antibiotics on survival in immunotherapy treated gastrointestinal cancers.2026