What question did this study set out to answer?

The study aimed to evaluate the effect of pathological complete response on overall survival and disease-free survival in esophageal carcinoma patients following neoadjuvant therapy.

May 29, 2026Journal of Clinical Oncology

Incidence and prognostic impact of recurrence in esophageal carcinoma patients achieving complete pathological response after neoadjuvant chemoradiotherapy or perioperative chemotherapy.

View Full Paper

Ask AI

Bookmark

The study aimed to evaluate the effect of pathological complete response on overall survival and disease-free survival in esophageal carcinoma patients following neoadjuvant therapy.
Retrospective analysis of 546 patients undergoing curative-intent esophagectomy from a prospective database.
Inclusion of patients receiving neoadjuvant therapy (nCRT or perioperative chemotherapy).
Survival outcomes analyzed using Kaplan-Meier curve during median follow-up of 5 years.
Pathological complete response (pCR) achieved in 54.8% of patients.
Recurrence rate was 27.1%, with only 28.3% in the pCR group (p < 0.001).
Mean overall survival in pCR group was 57 ± 0.7 months, compared to 52 ± 1 months in non-pCR group (p = 0.001).

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Retrospective analysis shows pathological complete response improves survival outcomes in esophageal carcinoma patients, highlighting significant prognostic implications.

Cite This Study

Aimon et al. (2026) studied this question.

synapsesocial.com/papers/6a192e95fab5b468c4417aab https://doi.org/10.1200/jco.2026.44.16_suppl.4069

View Full Paper

Ask AI

Bookmark

Implication

Retrospective analysis shows pathological complete response improves survival outcomes in esophageal carcinoma patients, highlighting significant prognostic implications.

Incidence and prognostic impact of recurrence in esophageal carcinoma patients achieving complete pathological response after neoadjuvant chemoradiotherapy or perioperative chemotherapy.

Key Points

Discussion

Implication

Cite This Study

Incidence and prognostic impact of recurrence in esophageal carcinoma patients achieving complete pathological response after neoadjuvant chemoradiotherapy or perioperative chemotherapy.

Key Points

Discussion

Implication

Cite This Study

Also Consider

Also Consider