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May 29, 2026Open Access

The Total Synthesis of Aleutianamine, (–)-Crotonolide D, and (–)-Crotonine G

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Authors

HYHao Yu

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Overview

Total synthesis identifies novel methods for creating drug candidates with specific cytotoxic effects.

Key Points

  • The aim is to achieve the total synthesis of aleutianamine and related compounds, highlighting new synthetic methods.
  • Developed initial a-thioketone derivatization approach, later employing palladium-catalyzed Barbier addition.
  • Introduced one-pot Larock indolization/Buchwald-Hartwig amination for tricyclic diaminoindole derivatives.
  • Utilized SmI₂ mediated cyclization and palladium-catalyzed carbonylation for crotonolide D and crotonine G.
  • Achieved total synthesis of aleutianamine with IC₅₀ = 25 nM against pancreatic cancer cells.
  • Constructed complex quaternary carbons for crotonolide D and crotonine G using radical cyclization techniques.
  • Developed novel methods for chemoselective substance introduction that could enhance drug development.

Cite This Study

Hao Yu (2026) studied this question.

synapsesocial.com/papers/6a192ea9fab5b468c4417ce5https://doi.org/10.7907/cn84-6g19
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