Abstract Background: The anthropogenic proliferation of per- and polyfluoroalkyl substances (PFAS) represents an unprecedented shift in global ecotoxicology. While localized toxicity is well-documented, the systemic, planet-wide capacity of these "forever chemicals" to induce a fundamental restructuring of the Earth's evolutionary trajectory remains unquantified within current planetary boundaries frameworks. Objectives: This study models the long-term, cross-trophic impacts of global PFAS accumulation to evaluate its potential to trigger an irreversible biosphere collapse, ocean acidification, and subsequent macro-ecological trophic regression. Methods: Utilizing a dynamic, non-steady-state multimedia fate and transport model coupled with a multi-species food chain toxicokinetic matrix, we simulated the global partitioning, long-range environmental transport (LRET), and surfactant-driven interfacial mass transfer kinetics of persistent fluorinated compounds over a 200-year horizon. Results: Our simulations demonstrate that the continuous transgression of the novel entities planetary boundary by PFAS drives a poorly reversible, systemic ecotoxicological collapse operating across multiple planetary boundaries. At the base of the biosphere, the model reveals a critical impairment of phytoplankton photosynthesis, severe inhibition of carbon fixation, and subsequent primary marine productivity (Pₚrimary) disruption. This micro-algal inhibition fundamentally disrupts the Earth's biological carbon pump, driving intense ocean acidification (dpH/dt) and accelerating global warming trajectories (d (delta T) /dt). This thermal surge triggers a catastrophic positive feedback loop: it forces the thermodynamic breakdown of cryospheric terminal sinks, releasing historically sequestered PFAS back into the marine matrix, while simultaneously reducing planetary albedo through the loss of polar ice caps and dark-water microbial proliferation. In higher trophic levels, this bioamplification acts synergistically with co-occurring anthropogenic stressors (microplastics, heavy metals, surfactants, and viral pan-zootics), surpassing critical median effective concentration (EC50, n) thresholds and inducing universal reproductive failure across megafauna and apex predators. Conclusions: We conclude that the combined bottom-up energetic starvation, top-down reproductive collapse, and multi-boundary climate-carbon-acidification feedbacks accelerate a profound ecosystem simplification. If current emission trajectories persist, this multi-level disruption exerts an unprecedented selective evolutionary pressure, forcing an irreversible global ecological regression toward a simplified, low-level trophic state dominated exclusively by resilient microbial and fungal life.
Sergei Pushkin (Wed,) studied this question.