Unimolecular micelles as an effective carrier of poorly water-soluble nifuratel for selective in vivo anticervical cancer therapy via mucoadhesive dynamic hydrogels

Monika Gosecka; Mateusz Gosecki; Małgorzata Urbaniak; Ewelina Wielgus; Renata Gruszka; Monika Marcinkowska; Barbara Klajnert‐Maculewicz; Anna Janaszewska

doi:10.1039/d6tb00746e

January 1, 2026Journal of Materials Chemistry B

Unimolecular micelles as an effective carrier of poorly water-soluble nifuratel for selective in vivo anticervical cancer therapy via mucoadhesive dynamic hydrogels

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Key Points

This research aims to evaluate unimolecular micelles as drug carriers for improved delivery of nifuratel in cervical cancer therapy.
Utilized unimolecular micelles for enhanced solubility and bioavailability of nifuratel.
Applied mucoadhesive dynamic hydrogels to facilitate localized drug release.
Conducted in vivo experiments to assess anti-cancer efficacy.
Unimolecular micelles significantly improved the solubility of nifuratel, enhancing its therapeutic effects.
In vivo results showed a marked reduction in tumor size compared to control groups (exact metrics not disclosed).
Local delivery via hydrogels resulted in less systemic toxicity, indicating a safer treatment option.

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Implication

Demonstrates the effectiveness of unimolecular micelles for localized anticervical cancer therapy, suggesting substantial improvements in treatment delivery.

Abstract

Cervical cancer remains a significant global health challenge, accounting for over 340,000 deaths annually. Consequently, there is an urgent need for localized drug delivery systems that can effectively eradicate cancer...

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Gosecka et al. (2026) studied this question.

synapsesocial.com/papers/6a192ed7fab5b468c4418097 https://doi.org/10.1039/d6tb00746e

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Unimolecular micelles as an effective carrier of poorly water-soluble nifuratel for selective in vivo anticervical cancer therapy via mucoadhesive dynamic hydrogels

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Unimolecular micelles as an effective carrier of poorly water-soluble nifuratel for selective in vivo anticervical cancer therapy via mucoadhesive dynamic hydrogels

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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