Study of The Safety and Efficacy of Different Esomeprazole Containing Regimens for Eradication of Helicobacter Pylori Infection

Background: One of the most prevalent chronic bacterial illnesses affecting humans is Helicobacter pylori (H. pylori). Helicobacter pylori has colonized more than 50% of the global population. Infection with Helicobacter pylori can affect as many as 80% of the population in some nations, such as Egypt; however, this number varies widely around the globe. Aim and objectives: To determine which esomeprazole-containing regimens are safest and most effective in eliminating H. pylori infection. Patients and methods: This is a prospective observational study carried out on 120-patients. The material of the present study included H. Pylori patients who were recruited form Al-Hussein Hospital, internal medicine outpatient clinics from April 2023 and April2024. Results: H. pylori eradication rate after esomeprazole-based regimen was 70.8%. Eradication rate did not significantly differ between different esomeprazole-based regimens. Also, patients reported adverse events had significantly lower eradication rate of H. pylori. Conclusion: The overall eradication rate of H. pylori using esomeprazole-based regimens was 70.8%, indicating moderate efficacy across different treatment protocols. The eradication rates were similar across all five esomeprazole-based regimens, suggesting that the efficiency of the antibiotic combinations used was not significantly different.