Evaluation of Serum Eotaxin and Related Biomarkers in Focal and Generalized Epilepsy

Epilepsy is a common brain disorder, characterized by spontaneous recurrent seizures, with associated neuropsychiatric and cognitive comorbidities and increased mortality. Assessment of serum Eotaxin and related biomarkers offers useful information about neuroinflammatory activity and metabolic imbalance in epilepsy, and may have potential value as diagnostic and prognostic tools. The aim of this study was to evaluate the association between Eotaxin, Intelectin-1, Kynurenine, and Proprotein Convertase-1 and epilepsy. The study consisted of 90 subjects who were classified into three groups: 30 healthy controls, 31 patients with focal epilepsy, and 30 patients with generalized epilepsy. Serum samples were obtained, and biomarker concentrations were measured using the ELISA technique. Statistical analysis was performed using GraphPad software. The results of this study show a significant increase in serum Eotaxin, Intelectin-1, and kynurenine concentrations in the epileptic patients' group as compared with the normal group. The results also show a significant decrease in the levels of proprotein convertase in the two epileptic patient groups as compared to healthy subjects. These findings suggest that serum Eotaxin and related biomarkers may provide mechanistic insights into epileptogenic processes, support early detection, and help prevent complications in patients with epilepsy.