Predictors of tumor lysis syndrome in non-Hodgkin lymphoma hospitalizations.

11178 Background: Tumor lysis syndrome (TLS) is a life-threatening oncologic emergency in non-Hodgkin lymphoma (NHL) caused by rapid tumor cell breakdown and severe metabolic derangements. Although TLS is well recognized, most risk data derive from small cohorts or trials, limiting generalizability. We used a nationally representative inpatient dataset to identify predictors of TLS in hospitalized NHL patients. Methods: We performed a cross-sectional analysis of the National Inpatient Sample (2016–2020). Adult NHL hospitalizations were identified using ICD-10 codes. Survey-weighted chi-square tests and multivariable logistic regression evaluated demographic, clinical, and treatment predictors. Analyses accounted for the complex survey design. Statistical significance was defined as p<0. 05. Results: An estimated 350, 400 NHL hospitalizations were identified, of which 0. 79% had TLS. TLS patients were younger (65. 7 vs 69. 5 years, p < 0. 001) and demonstrated different racial distributions, with lower proportions of White patients (67. 8% vs 76. 9%) and higher proportions of Black (12. 7% vs 9. 2%) and Hispanic patients (11. 6% vs 8. 6%) (p < 0. 001). TLS occurred more frequently in hospitals in the West and Northeast (p = 0. 036). TLS admissions had significantly longer stays (10. 48 vs 5. 91 days) and higher charges (174, 972 vs 76, 884; p < 0. 001). Survey-weighted regression identified several strong predictors of TLS. Bone marrow involvement was one of the strongest independent predictors (OR 13. 78 95% CI 5. 45–34. 84). Electrolyte derangements were also powerful predictors: hyperkalemia (OR 8. 20 95% CI 6. 82–9. 86), hyperphosphatemia (OR 8. 28 95% CI 6. 62–10. 36), and hypocalcemia (OR 7. 02 95% CI 5. 67–8. 69). Additional predictors included sepsis (OR 2. 29 95% CI 1. 89–2. 77), neutropenia (OR 1. 71 95% CI 1. 27–2. 31), HIV infection (OR 1. 73 95% CI 1. 05–2. 84), and receipt of inpatient chemotherapy (OR 1. 38 95% CI 1. 01–1. 87). Prior chemotherapy (OR 0. 44 95% CI 0. 30–0. 63) and radiation therapy (OR 0. 61 95% CI 0. 38–0. 99) were protective, suggesting TLS risk is greatest in chemo-naïve or high–tumor burden presentations. Conclusions: TLS in hospitalized NHL patients is associated with distinct demographic patterns and substantial increases in healthcare utilization. Early risk stratification incorporating clinical, laboratory, and treatment factors may improve prevention strategies and outcomes. Predictors of TLS among hospitalized patients with NHL. Predictor Adjusted OR 95% CI p-value Bone marrow involvement 13. 78 5. 45–34. 84 <0. 001 Hyperkalemia 8. 20 6. 82–9. 86 <0. 001 Hyperphosphatemia 8. 28 6. 62–10. 36 <0. 001 Hypocalcemia 7. 02 5. 67–8. 69 <0. 001 Sepsis 2. 29 1. 89–2. 77 <0. 001 Neutropenia 1. 71 1. 27–2. 31 <0. 001 HIV infection 1. 73 1. 05–2. 84 0. 031 Inpatient chemotherapy 1. 38 1. 01–1. 87 0. 041 Prior chemotherapy 0. 44 0. 30–0. 63 <0. 001 Radiation therapy 0. 61 0. 38–0. 99 0. 046