Key result
Physical activity and cardiac rehab improve cardiovascular fitness and quality of life in patients undergoing HSCT.
Why the study?
As survival after HSCT improves, cardiovascular disease has become a significant cause of morbidity and mortality, warranting a framework for physical activity and cardiac rehabilitation.
Does physical activity and cardiac rehabilitation improve outcomes in patients undergoing hematopoietic stem cell transplantation?
Does physical activity and cardiac rehabilitation improve outcomes in patients undergoing hematopoietic stem cell transplantation?
Physical activity and cardiac rehabilitation appear beneficial for patients undergoing hematopoietic stem cell transplantation, though current evidence is limited by small sample sizes and methodological heterogeneity.
May support exercise in HSCT patients; limited evidence leaves optimal protocols open for larger trials.
Hematopoietic stem cell transplantation (HSCT) is a standard treatment for several malignancies, and >50,000 HSCT are performed annually worldwide. As survival after HSCT improves, cardiovascular disease and associated risk factors have gained importance as a significant cause of morbidity and mortality in this cohort. In this article, we detail the risk factors for cardiovascular disease and their impact in patients undergoing HSCT. Additionally, we critically review the data on the impact of physical exercise in patients undergoing HSCT. Although limited by significant heterogeneity in methodologies, small sample sizes, attrition, and lack of long-term cardiovascular follow-up, most of these studies reinforce the beneficial effects of physical activity and exercise in this patient population. Cardiac rehabilitation (CR) is a structured exercise and lifestyle modification program that is typically instituted in patients who experience acute cardiovascular events. We review the data on CR in the oncologic and nononcologic populations with an aim of building a framework for use of CR in HSCT patients.
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Mohananey et al. (2021) conducted a review in Hematopoietic Stem Cell Transplantation (HSCT). Physical Activity and Cardiac Rehabilitation was evaluated. Physical activity and cardiac rehabilitation improve cardiovascular fitness, strength, and quality of life, and decrease fatigue in patients undergoing hematopoietic stem cell transplantation.
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