THU-011 Cardiovascular health metrics (Life’s Essential 8) and the risk and trajectories in MASLD, type 2 diabetes, and comorbid disease: an international, multicenter cohort study

Key Points

• This research examines the relationship between cardiovascular health metrics and the development of MASLD and type 2 diabetes.
• Conducted as an international multicenter cohort study.
• Focused on participants with cardiovascular health metrics as specified by Life’s Essential 8.
• Analyzed risk trajectories associated with MASLD and comorbid diseases.
• Identified a significant association between poor cardiovascular health metrics and increased risk of MASLD.
• Documented elevated trajectories of type 2 diabetes prevalence correlating with decreasing cardiovascular health.
• Highlighted the role of Life’s Essential 8 in predicting trajectories for comorbid conditions.