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The author has identified two problems that need to be overcome in order that some of the powerful testing techniques be used in practice: performance and effectiveness. The testing methods referred to are dataflow and mutation testing.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
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Aditya P. Mathur (2002) studied this question.