Key result
Fontan circulation with chronic hypoxia in pregnancy was associated with recurrent placentomegaly and chorioangioma across three pregnancies in a 28-year-old patient.
Why the study?
The effects of Fontan circulation on the developing placenta and fetus are not completely understood, and chronic placental hypoxia may explain an increased incidence of chorioangioma.
Case Report (n=1)
No
Fontan circulation with chronic hypoxia in pregnancy may be associated with recurrent placentomegaly and chorioangioma, suggesting a need for targeted ultrasound screening.
May prompt enhanced placental surveillance in Fontan pregnancies; leaves open hypoxia's causal role in recurrent chorioangioma.
Introduction: The incidence of cardiac disease in pregnancy continues to increase, particularly pregnancy with complex congenital heart diseases. Fontan circulation is a unique circulation surgically created for individuals with single ventricle physiology, effects of which on developing placenta and fetus are not completely understood. Chronic placental hypoxia in Fontan circulation might explain increased incidence of chorioangioma in those patients.
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Abdelwahab et al. (2021) conducted a case report in Fontan circulation in pregnancy (n=1). Fontan circulation with chronic hypoxia in pregnancy was associated with recurrent placentomegaly and chorioangioma across three pregnancies in a 28-year-old patient.
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