Initiation of oral flecainide for atrial fibrillation can lead to the development of dangerous ventricular arrhythmias even in patients with a structurally normal heart, subjective improvement, and no QTc prolongation.
Antiarrhythmic drugs used for pharmacological cardioversion of AF include disopyramide, procainamide, quinidine, flecainide, propafenone (both class IC), dofetilide, ibutilide, sotalol, and amiodarone (all class III). However the most commonly used drugs for chemical cardioversion are flecainide, sotalol, and amiodarone. In patients with new onset AF, successful cardioversion is reported in approximately 80% of cases with oral therapy, increasing up to 90% with intravenous administration
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B Djamel (2014) studied this question.
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