Why the study?
Does concurrent glyceryl trinitrate therapy improve the thrombolytic efficacy of t-PA in a canine model of coronary thrombosis?
Does concurrent glyceryl trinitrate therapy improve the thrombolytic efficacy of t-PA in a canine model of coronary thrombosis?
Concurrent administration of glyceryl trinitrate with t-PA does not improve, and may actually impair, the thrombolytic efficacy of t-PA in a canine model of coronary thrombosis.
Does not support GTN with t-PA in coronary thrombosis; leaves open translation to human thrombolysis.
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Nicolini et al. (1991) studied this question.
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