Answers are grounded in this paper and cite their sources.
An automated, continuous flow droplet screening system is presented, enabling real-time simultaneous solvent and continuous variable optimization. An optimal design of experiments strategy is applied to the alkylation of 1,2-diaminocyclohexane in 16 μL droplets, with scale-up demonstrated. Analysis of segmented flow results suggests correlation of yield with solvent hydrogen bond basicity.
No takes yet. Share an insight, caveat, or question.
Reizman et al. (2015) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: