Why the study?
The efficiency of in vivo cardiac myofibroblast-to-cardiomyocyte-like cell reprogramming using stringent lineage tracing systems remained unclear, as activated myofibroblasts are more difficult to reprogram than resident cardiac fibroblasts.
This study investigates improved factor combinations for the in vivo reprogramming of activated cardiac myofibroblasts into cardiomyocyte-like cells to promote heart regeneration.
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Supports optimization of in vivo reprogramming in animal models; leaves open translation to human cardiac regeneration.
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Wu et al. (2023) studied this question.
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