The Head Stands Accused by the Heart! —Depression and Premature Death from Ischaemic Heart Disease

Background: The purpose of this study was to examine whether clinical depression was associated with higher risk of premature death from ischemic heart disease (IHD). Risk for IHD was examined separately by sex and sub-type of depression in a long-term follow-up study spanning 49 years. Method: Patients who were diagnosed with depression in the Chichester/Salisbury Catchment Area Study were followed for 49 years. Observed deaths from IHD prior to the age of 70 were compared with rates that were predicted from historical data on mortality rates from 1960 onwards. Results: Significantly higher rates of death from IHD before the age of 70 were found among males with endogenous depression. Conclusions: The results are discussed in terms of the broader literature on mortality from natural causes among patients with clinical depression. In terms of prevention, the results indicate that patients diagnosed with severe clinical depression particularly men at the very least warrant risk assessment with regard to IHD.