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MOTIVATION: We introduce HaploGrouper, a versatile software to classify haplotypes into haplogroups on the basis of a known phylogenetic tree. A typical use case for this software is the assignment of haplogroups to human mitochondrial DNA (mtDNA) or Y-chromosome haplotypes. Existing state-of-the-art haplogroup-calling software is typically hard-wired to work only with either mtDNA or Y-chromosome haplotypes from humans. RESULTS: HaploGrouper exhibits comparable accuracy in these instances and has the advantage of being able to assign haplogroups to any kind of haplotypes from any species-given an extant annotated phylogenetic tree defined by sequence variants. AVAILABILITY AND IMPLEMENTATION: The software is available at the following URL https: //gitlab. com/bioₐnthdecode/haploGrouper. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.
Jagadeesan et al. (Wed,) studied this question.