LSD and JB318: A Comparison of Two Hallucinogens

Introduction Lysergic acid diethylamide (LSD-25) has been the most commonly employed hallucinogenic agent in psychopharmacologic studies. LSD-induced changes in mood, thought, perception, and behavior and in psychological test performance have been widely studied.¹⁻⁸More recently JB 318 (N-ethyl-3-piperidyl benzilate), a psychotomimetic drug with atropine-like autonomic effects, has been described.⁹,¹⁰For several reasons, it was deemed advisable to compare the effects of the two agents on the same population, utilizing the same techniques of measurement. First, the LSD psychosis has become a sort of standard of reference among psychotomimetic agents, and newer drug effects may be better understood when compared with the standard. It was further postulated that in a direct comparison study, differences and similarities in the effects of the two drugs could be defined relatively clearly. If both agents were administered at least in part, to infer what aspects of to the same subjects, it should