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Lignocellulosic biorefinery constitutes a critical pillar for transitioning the fossil-based industrial paradigm toward sustainability. However, in lignocellulosic biorefinery, cross-interference between cellulose, hemicellulose, and lignin persists throughout all steps. Effective regulation must extend beyond pretreatment across the entire process. Here, we develop a whole-process regulation strategy for corn stover. Mechanical fractionation homogenizes physical structure, yielding parenchyma-rich short fibers and vascular-bundle-dominant long fibers. For highly degradable short fibers, molecular control by methanol during steam explosion suppresses lignin condensation, followed by oxidative enhancement by carbon quantum dots during enzymatic hydrolysis, boosting cellulose conversion and facilitating mild lignin depolymerization for high-performance epoxy resins. For high-crystallinity long fibers, two-stage selective enzymatic hydrolysis preserves crystallinity to produce cellulose nanocrystals. Techno-economic analysis shows a 36.7% revenue increase over the unregulated baseline. This integrated approach embodies the concept of precision biorefinery: a transformative framework where whole-process regulation orchestrates multi-level heterogeneity-guided fractionation to enable full-component directed valorization, ensuring compatibility between biomass attributes, process, and product specifications. The concept and innovations have been industrially validated.
Lin et al. (Thu,) studied this question.