Oxprenolol—A Beta-Blocking Agent in the Treatment of the Climacteric

Fifty-six patients with symptoms attributable to the menopause, were given either oxprenolol 80 mg three times a day or the general practitioner's normal therapy. Allocation to either treatment was done randomly. Thirty patients were given oxprenolol—26 patients were given the doctor's usual therapy each for 1 month. Both treatments significantly reduced the number of hot flushes per day, but there was no significant difference between them. Other parameters measured were tension, headaches, sleep and depression, and again both treatments were relatively effective, without any significant difference between them. The merits of the various therapeutic approaches to the menopausal syndrome are discussed.