Parental early onset hypertension (<55 years) increased offspring hypertension risk (HR 2.0 for one parent, 3.5 for both), and early onset (<45 years) increased odds of cardiovascular death (OR 2.2).
Cohort (n=5,249)
Does early onset hypertension increase the risk of hypertension in offspring and cardiovascular death compared to late onset or no hypertension?
Early onset hypertension is a distinct familial trait that strongly predicts hypertension in offspring and significantly increases the risk of cardiovascular death compared to late onset hypertension.
Estimación del efecto: HR 2.0 (95% CI 1.2 to 3.5)
Objective To determine the role of early onset versus late onset hypertension as a risk factor for hypertension in offspring and cardiovascular death. Design Multigenerational, prospective cohort study. Setting Framingham Heart Study. Participants Two generations of community dwelling participants with blood pressure measurements performed at serial examinations spanning six decades: 3614 first generation participants with mortality data and 1635 initially non-hypertensive second generation participants with data available on parental blood pressure. Main outcome measures The main outcome measures were relation of parental early onset hypertension (age Results In second generation participants, having one or both parents with late onset hypertension did not increase the risk of hypertension compared with having parents with no hypertension; by contrast, the hazard ratios of hypertension were 2.0 (95% confidence interval 1.2 to 3.5) and 3.5 (1.9 to 6.1) in participants with one and both parents with early onset hypertension, respectively. In first generation decedents, 1151 cardiovascular deaths occurred (including 630 coronary deaths). The odds of cardiovascular death increased linearly with decreasing age of hypertension onset (PConclusions Early onset and not late onset hypertension in parents was strongly associated with hypertension in offspring. In turn, early onset compared with late onset hypertension was associated with greater odds of cardiovascular, and particularly coronary, death. These findings suggest it may be important to distinguish between early onset and late onset hypertension as a familial trait when assessing an individual’s risk for hypertension, and as a specific type of blood pressure trait when estimating risk for cardiovascular outcomes in adults with established hypertension.
Niiranen et al. (Fri,) conducted a cohort in Hypertension (n=5,249). Early onset hypertension (age <55 years) vs. Late onset hypertension or no hypertension was evaluated on Incidence of hypertension in offspring (one parent with early onset hypertension vs no hypertension) (HR 2.0, 95% CI 1.2 to 3.5). Parental early onset hypertension (<55 years) increased offspring hypertension risk (HR 2.0 for one parent, 3.5 for both), and early onset (<45 years) increased odds of cardiovascular death (OR 2.2).
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