Why the study?
The prospective relationship between baseline and long-term trajectories of the triglyceride-glucose index and cardiovascular disease risk in people living with HIV remained unexplored.
Does a higher triglyceride-glucose (TyG) index or a high-increasing trajectory increase the risk of cardiovascular disease in people living with HIV?
Population
16,122 treatment-naive PLWH initiating ART in China
Comparison
TyG index trajectories and baseline levels
Design
Prospective cohort study
Follow-up
Median 70 months
Key result
Each 1-standard deviation increase in the baseline triglyceride-glucose index was associated with a 39% higher risk of cardiovascular disease (HR 1.39) in people living with HIV.
Authors
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TyG index may aid CVD risk assessment in HIV; leaves open whether targeting it improves outcomes.
Cohort (n=16,122)
No
Does a higher triglyceride-glucose (TyG) index or a high-increasing trajectory increase the risk of cardiovascular disease in people living with HIV?
Effect estimate: HR 1.39 (95% CI 1.22, 1.59)
p-value: p=<0.001
Higher baseline triglyceride-glucose (TyG) index levels and a high-increasing trajectory are significantly associated with an increased risk of cardiovascular disease in people living with HIV, particularly in men.
Luo et al. (2025) conducted a cohort in HIV (n=16,122). Triglyceride-glucose (TyG) index vs. Lower TyG index levels was evaluated on Cardiovascular disease (CVD) (HR 1.39, 95% CI 1.22, 1.59, p=<0.001). Each 1-standard deviation increase in the baseline triglyceride-glucose index was associated with a 39% higher risk of cardiovascular disease (HR 1.39) in people living with HIV.