Key result
This review summarizes evidence on the antidiabetic effects of brain-derived neurotrophic factor and its association with platelet reactivity and inflammatory cytokines in type 2 diabetes mellitus.
BDNF may play a significant role in modulating platelet reactivity, inflammation, and glucose metabolism in patients with type 2 diabetes mellitus.
BDNF's metabolic and inflammatory links in type 2 diabetes merit targeted study; leaves open any clinical role pending interventional trials.
Brain-derived neurotrophic factor (BDNF) is a neurotrophin, which plays an important role in the central nervous system, and systemic or peripheral inflammatory conditions, such as acute coronary syndrome and type 2 diabetes mellitus (T2DM). BDNF is also expressed in several nonneuronal tissues, and platelets are the major source of peripheral BDNF. Here, we reviewed the potential role of BDNF in platelet reactivity in T2DM and its association with selected inflammatory and platelet activation mediators. Besides that, we focused on adipocytokines such as leptin, resistin, and adiponectin which are considered to take part in inflammation and both lipid and glucose metabolism in diabetic patients as previous studies showed the relation between adipocytokines and BDNF. We also reviewed the evidences of the antidiabetic effect of BDNF and the association with circulating inflammatory cytokines in T2DM.
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Eyileten et al. (2017) conducted a review in Type 2 Diabetes Mellitus. Brain-Derived Neurotrophic Factor (BDNF) was evaluated. This review summarizes evidence on the antidiabetic effects of brain-derived neurotrophic factor and its association with platelet reactivity and inflammatory cytokines in type 2 diabetes mellitus.
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