Treatment of lymphosarcoma in the dog with L-asparaginase

Three dogs with advanced lymphosarcoma were treated with L-asparaginase from E. coli. All three responded to therapy by marked regression of lymph nodes and dramatic improvement in general condition without evidence of toxicity. Two dogs returned temporarily to normal health and were clinically free of disease; the other showed a marked partial remission. One of the three dogs has remained in good health for 50 days after treatment was discontinued although the disease now shows signs of recurrence. Early relapse in the other two cases may be attributed to insufficient dosage of L-asparaginase.