Gene Therapy for Hereditary Hearing Loss

No AccessPerspectives on Hearing and Hearing Disorders: Research and DiagnosticsArticle1 May 2013Gene Therapy for Hereditary Hearing Loss Devin S. McDougald, Lisa L. Cunningham and Wade W. Chien Devin S. McDougald National Institute on Deafness and Other Communication Disorders, National Institutes of HealthRockville, MD Google Scholar More articles by this author , Lisa L. Cunningham National Institute on Deafness and Other Communication Disorders (NIDCD), National Google Scholar More articles by this author and Wade W. Chien Institutes of Health (NIH), and received funding for the work of this article from the NIDCD, Division of Intramural Research Google Scholar More articles by this author https://doi.org/10.1044/hhd17.1.5 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationTrack Citations ShareFacebookTwitterLinked In Mutations in over 70 genes have now been identified as causing hereditary hearing loss in humans. This expanding knowledge about the genetics of hearing loss opens the door for the development of gene therapies aimed at restoring hearing function by delivering corrective DNA to the inner ears of patients with hearing loss caused by these mutations. This review summarizes some of the recent advances toward the goal of developing gene therapy as a treatment for hereditary hearing loss in humans. References Akil, O., Seal, R. P., Burke, K., Wang, C., Alemi, A., During, M., … Lustig, L. R. (2012). Restoration of hearing in the VGLUT3 knockout mouse using virally mediated gene therapy.Neuron, 75, 283–293. Google Scholar Al-Dosari, M. S., & Gao, X. (2009). Nonviral gene delivery: Principle, limitations, and recent progress.AAPS Journal, 11, 671–681. Google Scholar Alba, R., Bosch, A., & Chillon, M. (2005). Gutless adenovirus: Last-generation adenovirus for gene therapy.Gene Therapy, 12(Suppl. 1), S18–27. Google Scholar Asokan, A., Schaffer, D. V., & Samulski, R. J. (2012). 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