Immune status of children with obstructive sleep apnea/hypopnea syndrome

OBJECTIVE: We aimed to evaluate the immune status of children with obstructive sleep apnea/hypopnea syndrome (OSAHS). METHODS: Fifty children with OSAHS having the symptoms of "snoring, mouth breathing and suffocating during sleep", who were admitted in our hospital from May 2014 to May 2016, were randomly selected. Another 52 healthy, age- and gender-matched children were enrolled as control subjects after taking informed consent. After admission, the peripheral venous blood was collected. T cell subsets and cytokines were analyzed by flow cytometry. Immunoglobulin and complement levels were detected by immunoassay analyzer. RESULTS: T lymphocytes (P>0.05). OSAHS group had significantly higher serum levels of IL-4, IL-6, IL-10 and IFN-γ than those of control group (P0.05). The serum IgA and C3 levels of OSAHS group significantly exceeded those of control group (P0.05). CONCLUSION: ratio, suggesting this group had poor immune function. Increase in humoral immune-related indices IL-4, IL-6, IL-10 and IFN-γ indicated the occurrence of oxidative stress and systemic inflammatory status.