In vitro study reveals Swertia chirayita metabolites protect HepG2 cells against acetaminophen toxicity, indicating CYP2E1 inhibition as a key mechanism.
< .05) and maximum antioxidant and hepatocyte protection compared to other fractions. UPLC-QTOF-HRMS analysis reveals that it contains 17 secondary metabolites various classes. Identified molecules showed potential interactions with the crucial amino acid residues in the active site of CYP2E1 protein indicate the possibility of inhibition which may counter APAP induced toxicity in HepG2 cells.
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Verma et al. (2024) studied this question.
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