What does this research mean for the field?

Transmural pressure and Angiotensin II act synergistically to enhance vascular fibronectin expression, an effect mediated by AT1 receptors and the stimulation of a local renin-angiotensin system. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

July 1, 1996Circulation Research

Pressure and Angiotensin II Synergistically Induce Aortic Fibronectin Expression in Organ Culture Model of Rabbit Aorta

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Structured PICO

Population

3-day organ culture model of rabbit aorta

Intervention

Angiotensin II (Ang II) and Ang II inhibitors (losartan, ACE inhibitors) combined with varying transmural pressures (0, 80, 150 mm Hg)

Comparator

Different pressure levels without Ang II, or relaxed vessels (0 mm Hg)

Outcome

Fibronectin (FN) expression and FN mRNA expressionsurrogate

Transmural pressure and Angiotensin II act synergistically to enhance vascular fibronectin expression via AT1 receptors in a rabbit aorta model.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Pressure-Ang II synergy may drive hypertensive vascular remodeling in models; extends animal data but leaves human translation open.

Cite This Study

Bardy et al. (1996) studied this question.

synapsesocial.com/papers/6a1a1cf6443d3ecd7cdf5cf6 https://doi.org/10.1161/01.res.79.1.70

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Pressure and Angiotensin II Synergistically Induce Aortic Fibronectin Expression in Organ Culture Model of Rabbit Aorta

Structured PICO

Discussion

Implication

Cite This Study

Pressure and Angiotensin II Synergistically Induce Aortic Fibronectin Expression in Organ Culture Model of Rabbit Aorta

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider