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The glucose consumption rate of 9L rat brain tumor cells was determined as a function of concentration. Glucose uptake followed Michaelis-Menten kinetics with a Km of 0.58 mM and a vmax of 1.6 pg/cellmin. The glucose diffusion coefficient in spheroids of 9L tumor cells was determined to be 1.5 × 10−6 cm2/s at 37°C. Using these parametric values, the glucose distribution in 9L multicell spheroids was calculated and related to the viable and necrotic zones.
Conan K. N. Li (Mon,) studied this question.
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