What does this research mean for the field?

Newly diagnosed cancer is associated with increased anatomical severity of coronary artery disease, but this relationship is only significant in patients with high levels of systemic inflammation. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

January 24, 2024BMC Cardiovascular DisordersOpen Access

Effect of inflammation on association between cancer and coronary artery disease

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Why the study?

Cancer and CAD often coexist, but whether cancer is directly associated with the anatomical severity of CAD and the effect of inflammation on this relationship were rarely studied.

Is newly diagnosed cancer associated with increased anatomical severity of coronary artery disease, and does inflammation affect this relationship?

Structured PICO

Is newly diagnosed cancer associated with increased anatomical severity of coronary artery disease, and does inflammation affect this relationship?

Population

1,496 patients who underwent coronary angiography (CAG), including 374 with newly diagnosed cancer (without previous anti-cancer therapy) and 1,122 non-cancer patients matched 1:3 by age and gender. Mean age 65.7, 74.3% male, based in China. Excluded: infection, autoinflammatory diseases, previous percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG).

Intervention

Newly diagnosed cancer (observational exposure)

Comparator

Non-cancer patients (1:3 propensity score matched by age and gender)

Outcome

Anatomical severity of CAD assessed using SYNTAX score (SXscore) based on coronary angiographic image, specifically high SXscore (>22)surrogate

Newly diagnosed cancer is independently associated with greater anatomical severity of coronary artery disease, an effect that appears to be driven by high systemic inflammation.

Limitations

Single-center retrospective cross-sectional study, which may introduce bias in enrolled patients, data collection, and analysis
Lack of data on patients' drug use (aspirin, statins, and ACEI)
Incomplete cancer staging and grading data to assess cancer severity at diagnosis
Sample size not big enough to investigate the correlation between different types of cancer and CAD

Authors

MSMingzhuang SunChinese PLA General Hospital SZShaoning ZhuChinese PLA General Hospital YWYihao WangLudwig Cancer Research

Discussion

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Implication

Cancer-associated CAD severity in high-inflammation patients warrants vigilance but should not yet change practice; leaves open causal and therapeutic implications.

Cite This Study

Sun et al. (2024) studied this question.

synapsesocial.com/papers/6a1a30b2db849bfdc47fca27 https://doi.org/10.1186/s12872-023-03613-0

Topics

Coronary artery disease

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Implication

Cancer-associated CAD severity in high-inflammation patients warrants vigilance but should not yet change practice; leaves open causal and therapeutic implications.