Why the study?
A lack of head-to-head trials comparing NOACs makes selecting a specific agent challenging for stroke prevention in AF.
Does non-vitamin K antagonist oral anticoagulants reduce stroke and systemic embolism in Asian/Vietnamese patients with atrial fibrillation compared to vitamin K antagonists?
Does non-vitamin K antagonist oral anticoagulants reduce stroke and systemic embolism in Asian/Vietnamese patients with atrial fibrillation compared to vitamin K antagonists?
This review highlights that NOACs should be the preferred anticoagulation strategy over VKAs for stroke prevention in Vietnamese patients with AF due to a favorable efficacy and safety profile, particularly regarding lower intracranial hemorrhage risk.
Supports NOAC preference in Asian AF; leaves open dedicated Vietnamese RCTs for confirmation.
In Asia, especially Vietnam, AF is a common arrhythmia and is linked to a higher risk of stroke and systemic embolism. Anticoagulation therapy for stroke prevention in AF patients can result in bleeding complications. To effectively manage AF, adopting appropriate anticoagulation and addressing modifiable risk factors are crucial. Vietnamese clinicians are particularly interested in non-vitamin K antagonist oral anticoagulants (NOACs), a recent development in AF treatment. However, the lack of head-to-head trials comparing NOACs makes selecting a specific NOAC challenging. This review aims to provide a comprehensive overview of the available clinical evidence on NOACs for stroke prevention in AF to assist clinicians in making informed decisions and improving treatment outcomes in patients with AF. The first part of this review will present the current landscape of AF in Vietnam, focusing on AF prevalence and highlighting gaps in clinical practice. Furthermore, this part extensively discusses the anticoagulation strategy for both primary and secondary stroke prevention in AF.
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Ho et al. (2023) studied this question.
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