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AIMS: The aim of this study was to investigate whether the shelf-life of diagnostic antibodies is longer than the expiry date on the label. METHODS AND RESULTS: Four independent laboratories tested a small number of diagnostic antibodies kept at +4°C for 12-26 years, and found them to work perfectly on routine histology sections. CONCLUSIONS: Diagnostic antibodies may have a workable half-life in excess of 10 years, and the emphasis on performance should shift to the preservation of antigenic targets in the tissue.
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Argentieri et al. (2013) studied this question.
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