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Aim: Several lines of evidence from various scientific approaches indicate that alcohol dependence (AD) in humans is genetically influenced. The aim of this review is to report recent findings, new approaches and developments in revealing the genetic underpinnings of alcohol dependence in humans. Results: Results mainly from marker-dependent studies (linkage, case-control association and genome-wide association) and intermediate phenotypes (endophenotypes) are reported as well as findings from recent pharmacogenomic and epigenetic research on alcohol use disorders. Based on the findings, potential perspectives for future research are discussed.
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Preuss et al. (2012) studied this question.
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