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June 24, 2003CirculationOpen Access

C-Reactive Protein, Carotid Intima-Media Thickness, and Incidence of Ischemic Stroke in the Elderly

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Why the study?

Does elevated CRP increase the risk of incident ischemic stroke independent of carotid IMT in elderly individuals?

Population

5417 participants aged 65 years or older without preexisting stroke or chronic atrial fibrillation from the…

Comparison

Elevated baseline C-reactive protein levels vs Lowest quartile of baseline CRP

Design

Cohort

Follow-up

10.2 years

Authors

JCJie CaoCTChau ThachTMTeri A. Manolio

Discussion

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Overview

Elevated CRP associated with higher ischemic stroke risk independent of carotid IMT in elderly; hypothesis-generating, should not yet change practice.

Structured PICO

Does elevated CRP increase the risk of incident ischemic stroke independent of carotid IMT in elderly individuals?

P
Population
5417 participants aged 65 years or older without preexisting stroke or chronic atrial fibrillation from the Cardiovascular Health Study
I
Intervention
Elevated baseline C-reactive protein (CRP) levels (analyzed by quartiles)
C
Comparator
Lowest quartile of baseline CRP
O
Outcome
Incident ischemic strokehard clinical

Elevated CRP is an independent risk factor for ischemic stroke in the elderly, with the association being more pronounced in the presence of higher carotid IMT.

Cite This Study

Cao et al. (2003) studied this question.

synapsesocial.com/papers/6a1a68da49c6765e38856b38https://doi.org/10.1161/01.cir.0000079160.07364.6a
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