Why the study?
How do lipid peroxidation and antioxidant capacity correlate with perioperative outcomes in adults undergoing on-pump CABG?
How do lipid peroxidation and antioxidant capacity correlate with perioperative outcomes in adults undergoing on-pump CABG?
Reduced antioxidant capacity and increased lipid peroxidation during cardiopulmonary bypass correlate with increased markers of myocardial damage.
These associations suggest oxidative stress monitoring in on-pump CABG; leaves open whether targeting TAC or HLP improves outcomes.
According to the findings, a direct correlation between TAC and myocardial protection during CPB exists. Reduced TAC during CPB is associated with elevation of muscle damage marker CPK. Preoperative HLP is associated with higher circulatory MDA content at the post-CPB time.
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Kachoueian et al. (2022) studied this question.
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