Cohort study examines stress impact on telomere length via DNA repair gene expression, suggesting biological effects of stress.
• Stress-related DNA repair–telomere dynamics were examined across two cohorts • DNA repair–telomere associations emerged in highly burdened groups • Mild cumulative lifetime stress moderated PARP1–telomere associations • Under a higher stress range, PARP1 and XRCC1 were linked to shorter telomeres • Findings support stress-related alterations in cellular maintenance
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Keppler et al. (2026) studied this question.
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