Long COVID symptoms before and 3-35 Months after SARS-CoV-2 infection in a Norwegian prospective cohort study, symptoms over the pandemic and different virus variants

Abstract (200/200) Objectives Examine long COVID symptoms, prevalence of symptoms over the pandemic, and compare symptoms due to the Omicron variants with symptoms due to earlier variants of the SARS-CoV-2 virus. Methods In the present Norwegian prospective cohort study 115737 persons, 18–96 years, completed 1-6 questionnaires 3-35 months after a positive and/or negative SARS-CoV-2 test between 2020–2023. Results The following symptoms were reported more frequently 3-35 months after than before positive SARS-CoV-2 test (n=37400): worsening of health, (OR 1.79 [CI 1.71–1.86]), memory problems (2.21 [2.06–2.37]), concentration problems (1.98 [1.87–2.09]), dyspnea (1.95 [1.84–2.07]), fatigue (1.46 [1.41–1.52]) and smell/taste changes (3.12 [2.84–3.42]). The prevalence of symptoms was lower at the end of 2022 than in 2020. A positive SARS-CoV-2 test during the Omicron-dominated period was associated with lower prevalence of symptoms than a positive test during the period dominated by earlier variants. Conclusions Several symptoms lingered up to 35 months post-SARS-CoV-2 infection. The prevalence of symptoms decreased over the course of the pandemic and were reported less often in those infected with later SARS-CoV-2 variants than earlier variants. The indications of long-term persisting symptoms after COVID-19 and the consequences of new variants should be further monitored.