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Demonstrates SPARC's influence on collagen assembly in musculoskeletal tissues, indicating its importance in maintaining tissue health.
• SPARC regulates collagen fibrillogenesis and ECM organization. • SPARC modulates cell-matrix interactions and mechanotransduction. • Tissue-specific roles across musculoskeletal tissues (tendon, bone, muscle, cartilage, and intervertebral discs). • SPARC supports tissue homeostasis and repair. • SPARC dysregulation contributes to degeneration and disease.
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Cesur et al. (2026) studied this question.
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